INTRODUCTION
Skin expansion is a physiological process defined as the ability of human skin to
increase its superficial area in response to stress or to a given deformation.
Skin expanders are silicon prostheses of different shapes and sizes that are
implanted underneath the skin. Because the skin exhibits creep or relaxation,
the resulting stress decreases after a specific amount of time due to an imposed
deformation. The physiology of skin expansion not only consists of the
stretching of skin but also includes the relaxation process involved to obtain
an extra flap of skin with specific characteristics.
Since the study conducted by Austad & Rose1, several authors such as Schmidt et al.2 have attempted to improve the expansion process using
self-inflating or continuous and controlled expansions, such as Duffy &
Shuter3. Several authors have also
examined concepts and complications involved in the surgical process, and there
have been numerous studies describing the findings associated with skin
expansion from a medical perspective. However, few studies have investigated the
bioengineering process.
A question that arises during skin expansion is with regards to the pressure
inside the expander, which is important for determining if infiltration should
proceed. Presently, the doctor does this intuitively.
When monitoring the internal pressure and injected volume during several skin
expansions, Pamplona & Mota4 observed
discrepancies in expansion when the prosthesis is located over fatty tissues. To
monitor the skin expansion and check and identify the behaviour of the skin
resulting from successive skin expansions, it was necessary to measure the
pressure inside the skin expander before, during, and after injection of the
saline solution for each expansion5-7.
OBJECTIVE
To study the process of skin expansion, a portable liquid infiltration device was
designed and constructed that can record the relationship between the internal
pressure and the volume of the fluid infiltrated during skin expansion as well
the monitoring of internal pressure over time. This semiautomatic system aims to
assist the surgeon in the skin expansion procedure, as well as enabling the
process to be performed by the patient, following the doctor’s guidelines.
Thus, a patient in remote locations and with limited access to electricity can
perform the procedure semi-autonomously, eliminating the need for periodic
outpatient clinic attendance. The acquisition of the data from the expansion
will allow several subsequent studies: the examination of the decrease of
pressure from infusions in subcutaneous implants over time, the generation of
data to identify the viscoelastic parameters of the skin, the determination of
infiltration limits, the optimization of expanders and implants, and much
more.
METHODS
The device has an easy-to-carry and clean design protected by a carrying case,
which contains all the accessories required for use, as shown in Figure 1. Its operation features a
user-friendly, touch- sensitive interface for both patient and physician use. In
addition, throughout the infiltration process the user can control the pressure,
maximum flow and volume and has the capacity to stop the procedure at any
moment.
Figure 1 - Autonomous infuser: screen (a), pump (b), saline solution (c) and
electrical cord (d).
Figure 1 - Autonomous infuser: screen (a), pump (b), saline solution (c) and
electrical cord (d).
Only the doctor can adjust the settings and change the date and time; these are
password-protected. The doctor enters settings for each expander, to a maximum
of 5, for the maximum volume and pressure of each skin expansion as well as the
maximum total volume to be infiltrated. The process automatically stops when the
pressure reaches a critical value or when the total volume of infiltrated fluid
is reached. The peristaltic pump can both infiltrate and withdraw liquid from
the expander.
The patient uses the screen shown in Figure 2 to begin each infusion, selecting the skin expander to be
infiltrated, as this operation can be performed using several expanders. The
screen shows the actual pressure inside the expander, and the patient can
control the flow of the infiltration and is able to stop the process at any
point.
Figure 2 - Patient´s screens, where infusion begins.
Figure 2 - Patient´s screens, where infusion begins.
The data for each expansion are recorded separately in “.csv” files to relate
pressure and volume with the date and time. The pump is easily sterilized via a
removable, autoclave-resistant pump head, and the peristaltic pump does not come
into contact with the liquid.
RESULTS
To simulate the skin expansion process, an elastic membrane was used to simulate
the skin over a 200 mL round skin expander, as shown in Figure 3, which in turn is attached on the acrylic platform.
Using the device with four infiltrations containing volumes of approximately 50
mL on four consecutive days, the internal pressure vs. the internal volume in
the skin expander for each expansion, as shown in Figure 4.
Figure 4 - Internal volume vs. the internal pressure over
each expansion.
Figure 4 - Internal volume vs. the internal pressure over
each expansion.
From this figure it can be observed in the transition over days, the internal
pressure inside the expander decreases; it is believed to be due to the
viscoelastic properties of the membrane, which relaxes over time and which is
much less than that of the skin. Note that in the second expansion a different
behaviour is observed, where a dip in pressure, followed by a curve that does
not follow the previous trend. This may be due to the skin expander adjusting
itself over the acrylic base.
DISCUSSION
A proprietary design was developed in a waterproof case for portability, safety
and ease of handling with the ability to determine the pressure and volume,
display them on the touchscreen interface, and save them on a removable MicroSd
card, recording the date and time for as many as five expanders. In addition,
the device is powered by a rechargeable lithium-ion battery and uses a
programmable microcontroller.
CONCLUSIONS
To improve the skin expansion process, a portable liquid infiltration device was
designed and constructed that can record the relationship between the internal
pressure and the volume of the fluid infiltrated during the skin expansion as
well as monitoring the internal pressure over time. This semiautomatic system
can assist the surgeon in the skin expansion procedure, enabling the process to
be performed by the patient. Thus, a patient in a remote location and with
little access to electricity can perform the procedure.
The device motorizes and optimizes the expansion since the doctor can prescribe a
limit to each expansion for either the maximum pressure or the volume
infiltrated. All data are recorded, which provides an important and precise
database regarding skin behaviour for bioengineering medical studies relating to
gender, race, age and expansion site. The device successfully allows a new way
to perform skin expansion due to its portability and vast storage capacity.
Acknowledgements
We are grateful to late Professor Ivo Pitanguy and his staff for the support
given to our projects over the years.
COLLABORATIONS
DCP
|
Analysis and/or data interpretation, conception and design study,
conceptualization, funding acquisition, investigation, methodology,
project administration, realization of operations and/ or trials,
resources, supervision, validation, writing - original draft
preparation, writing - review & editing.
|
RCP
|
Conception and design study, conceptualization, data curation,
investigation, realization of operations and/or trials.
|
HIW
|
Analysis and/or data interpretation, investigation.
|
GRS
|
Methodology, realization of operations and/ or trials.
|
HNR
|
Conceptualization, final manuscript approval.
|
REFERENCES
1. Austad ED, Rose GL. A self-inflating tissue expander. Plast Reconstr
Surg. 1982;70(5):588-94.
2. Schmidt SC, Logan SE, Hayden JM, Ahn ST, Mustoe TA. Continuous
versus conventional tissue expansion: experimental verification of a new
technique. Plast Reconstr Surg. 1991;87(1):10-5.
3. Duffy JS, Shuter M. Evaluation of soft-tissue properties under
controlled expansion for reconstructive surgical use. Med Eng Phys.
1994;16(4):304-9.
4. Pamplona DC, Motta DEJS. Numerical and experimental analysis of
inflating a circular hyperelastic membrane over a rigid and elastic foundation.
Int J Mech Sci. 2012;65(1):18-23.
5. Pamplona DC, Carvalho CR. Characterization of human skin through
skin expansion. J Mech Mater Struct. 2012;7(7):641-55.
6. Pamplona DC, Velloso RQ, Radwanski HN. On skin expansion. J Mech
Behav Biomed Mater. 2014;29:655-62.
7. Pamplona DC, Weber HI, Leta FR. Optimization of the use of skin
expanders. Skin Res Technol. 2014;20(4):463-72.
1. Pontifícia Universidade Católica do Rio de
Janeiro, Rio de Janeiro, RJ, Brazil.
2. Instituto Ivo Pitanguy, Rio de Janeiro, RJ,
Brazil.
Corresponding author: Djenane Cordeiro Pamplona, Departamento de
Engenharia Mecânica da PUC-Rio, Rua Marquês de São Vicente nº 225 - Gávea - Rio
de Janeiro, RJ, Brazil, Zip Code 22451-900. E-mail:
djenane@puc-rio.br
Article received: May 17, 2018.
Article accepted: October 4, 2018.
Conflicts of interest: none.