Introduction: Loss of abdominal wall substance (LAWS) is clinically and surgically important because of its high incidence, the distress it causes, and the high cost of its current treatments. Recently, new techniques have been developed to treat LAWS, including the creation of flaps and use of biocompatible synthetic materials. The aim of this randomized uncontrolled experimental study was to assess the suitability of hemicellulose film for LAWS repair in rats. Methods: Forty female Wistar EPM III rats were divided into 4 groups (I-IV) of 10 animals each. All the animals received general anesthesia with 40 mg/kg intraperitoneal thiopental sodium. A 2.0 × 3.0 cm area of muscle-aponeurotic tissue and peritoneal damage was created in the anterior abdomen of every rat. Fifteen 2.0 × 3.0 cm hemicellulose films soaked in 0.9% saline were affixed in overlapping layers to the adjacent muscle walls with 8 separate 5-0 nylon sutures, and the skin and panniculus carnosus were synthesized by placing continuous 5-0 nylon sutures. The animals in groups I, II, III, and IV were euthanized after 3, 28, 35, and 240 days, respectively. Conclusion: Hemicellulose film is effective for repairing LAWS in rats.
Keywords: Abdominal wall/surgery. Implants, experimental. Rats. Histology.