INTRODUCTION
Abdominoplasty is a specific and effective procedure used to improve body contour1. Various improvements in the technique have been achieved by the combination of limited
dissection of the cutaneous flap and quilting sutures in the same surgery, thus avoiding
suture dehiscence and complications such as skin necrosis, hematoma, and seroma1. Postoperative abdominoplasty seroma is a rather high-prevalence complication (10-15%)
that troubles both patient and plastic surgeon2.
Seroma occurs mainly in patients with a high body mass index, those who experienced
significant weight loss, and in cases of prior supraumbilical incisions3. Another contributing factor is large abdominal flap detachment, which creates a
greater detached area for liquid collection that greatly devascularizes the flap and
causes greater lymphatic vessel damage4; this is reflected in the presence of dead space between the abdominal muscle aponeurosis
and the dermal fat flap postoperatively5.
The use of active drains is known to prevent the occurrence of seroma 4. One of the solutions proposed in the literature was widely described in the work
of Baroudi and Ferreira in 19986, which is based on the use of quilting sutures and reduction of dead space between
dissected tissues, culminating in the complete abolition of the use of drains and
absence of seroma in their sample of 130 patients6.
An analysis of the literature indicated a lack of consensus on the indication for
use of quilting sutures. A predominance of reports discuss another relevant surgical
technique, progressive tension sutures, which led us to develop this work. Thus, this
study aimed to evaluate whether the use of quilting sutures versus drains is associated
with a lower incidence of seroma after abdominoplasty.
METHODS
This systematic review of the literature with a meta-analysis questioned whether there
is a difference in the incidence of seroma in abdominoplasty with the use of drains
versus quilting sutures. To identify relevant studies, the following databases were
queried: Science Direct, Scopus, PubMed (medical Publications), LILACS (Literatura Científica e Técnica da América Latina e Caribe), Scielo (Scientific Electronic Library Online), and CINAHL (Cumulative Index to
Nursing and Allied Health Literature).
There were no restrictions on language or publication date, with all publications
published until 25 May 2018. The search strategy performed in PubMed included the
terms "abdominoplasty" [MeSH terms] OR "abdominoplasty" [All Fields] AND "drains"
[All Fields]. Equivalent search strategies were adopted for the other databases. To
identify additional studies, the references of the articles included were manually
checked and relevant publications on the subject were evaluated.
Among the articles that were identified through the search strategy, those that adequately
met the following inclusion criteria were selected: abdominoplasty comparing the use
of drains and/or quilting sutures with their respective seroma rates encompassing
both sexes. The exclusion criteria were: review articles, encyclopedias, book chapters,
case studies, or commentaries; and the use of surgical techniques that differ from
quilting sutures, for example, progressive tension sutures. These features were registered
in a protocol in the International Prospective Register of Systematic Reviews (PROSPERO;
no. CRD42019120399).
Two independent researchers assessed the titles and abstracts of the obtained articles
and identified all potentially eligible publications for full-text review. The data
extraction and final classification for inclusion in the review were performed independently.
The results were compared, and consensus was reached through discussion as needed.
The main information collected from each article was entered into a spreadsheet and
included the following: author and publication year, study type, sample size, age
range of study population, patient sex, year study was performed, intervention country,
intervention type (drain only, quilting sutures, drain with quilting sutures), follow-up
time, results, and recommendations/conclusions.
After collecting the information, the authors analyzed the methodological quality
using the instrument "Appropriate Use and Reporting of Uncontrolled Case Series in
the Medical Literature"7 since all studies that met the inclusion criteria were cases series. This scale has
seven items (Table 1): 1. Explicitly state the hypothesis/hypotheses under consideration; 2. Explicitly
provide eligibility criteria for subjects in the report; 3. Precisely describe how
treatments were administered or potential risk factors defined; 4. Compare observed
results to those in an appropriate external comparison group and discuss potential
biases arising from such comparison; 5. Perform appropriate statistics, ensuring that
assumptions of the statistical methods are reasonable in this setting; 6. Discuss
the biological plausibility of the hypothesis in light of the report's observations;
7. Explicitly discuss the report's limitations and how these limitations could be
overcome in future studies.
Table 1 - Scale of methodological quality "Appropriate Use and Reporting of Uncontrolled Case
Series in the Medical Literature" used to evaluate the included studies.
|
Arantes et. al. (2009)
|
Soncini; Baroudi (2016)
|
Oliveira et. al.(2008)
|
Sforza et. al.(2015)
|
Trufino et. al.(2015)
|
Explicitly state the hypothesis |
+ |
+ |
+ |
+ |
+ |
Eligibility criteria |
+ |
+ |
+ |
+ |
+ |
Treatments administered/ potential risk factors
|
? |
- |
+ |
+ |
+ |
Comparison with external group/ discussion of potential biases
|
+ |
- |
+ |
+ |
+ |
Statistical tests and limitations |
+ |
- |
+ |
+ |
- |
Concordance with the existing literature |
+ |
+ |
+ |
+ |
+ |
Discussion of limitations |
- |
- |
- |
+ |
+ |
Table 1 - Scale of methodological quality "Appropriate Use and Reporting of Uncontrolled Case
Series in the Medical Literature" used to evaluate the included studies.
The data were analyzed using the Stata 12.0 program (StataCorp LP, College Station,
TX, USA). To measure inconsistencies between studies (percentage of total variation
between studies due to heterogeneity), the I2 statistic proposed by Higgins (REF) was used with a 95% confidence interval (CI)
of the relative risk (RR) for seroma according to intervention type (drain, quilting
sutures, drain with quilting sutures). As the number of studies was small and had
little heterogeneity, there was no need for a further analysis.
RESULTS
Altogether, 437 articles were identified as potentially eligible for inclusion in
this review. After the exclusion of duplicate articles (n = 57), the titles and abstracts
of 380 articles were reviewed. Subsequently, 30 articles remained. Of them, 25 did
not meet the inclusion criteria and were subsequently excluded (Figure 1).
Figure 1 - Flowchart of the article selection process of studies of abdominoplasties comparing
the use of drains and/or quilting sutures
Figure 1 - Flowchart of the article selection process of studies of abdominoplasties comparing
the use of drains and/or quilting sutures
Only descriptive case series were identified for inclusion in the systematic review;
during the assessment of methodological quality, the article by Soncini and Baroudi
(2016)1 met the fewest criteria, while that by Sforza et al. (2015)8 met the most criteria. The discussion of limitations was most often lacking, while
all articles met the following criteria: clearly describe the hypothesis, specify
eligibility criteria, and state agreement with the existing literature (Table 1).
Of the included studies, the sample size ranged from 34 to 500 patients aged 23-75
years, there was a predominance of female patients, and the follow-up was 7-360 days
(Table 2). Regardless of intervention type and follow-up period, four studies showed a lower
rate of seroma formation using quilting sutures than suction drains. In addition,
in all studies, the same surgical team provided the interventions. Table 3 describes the data of the five studies with their respective results and recommendations/conclusions.
Table 2 - Characteristics of studies in the meta-analysis that show an association between seroma
and use of drain or quilting sutures.
Article |
N |
Age |
Year of surgery
|
Follow-up time (days)
|
Sex |
Seroma (%) |
D |
QS |
D + QS |
Arantes HL et al.2 |
60 |
|
2006-2007 |
7-14-30-60-120-180 |
F, 60 M=0 |
|
3.45 |
3.2 |
Soncini JA et al.1 |
500 |
24-75 |
2007-2014 |
- |
F, 490 M= 10 |
|
15.6 |
23.7 |
Oliveira EA et al.4 |
58 |
29-73 |
1999-2003 |
- |
F, 56 M= 2 |
28 |
3.33 |
0 |
Sforza M et al.8 |
326 |
28-57 |
2007-2011 |
7-14-28-360 |
F, 326 M= 0 |
12 |
|
0 |
Trufino AJ5 |
34 |
23-67 |
2008-2012 |
7-14-21-30-45-60-90-180-360 |
F, 34 M=0 |
17.6 |
0 |
|
Table 2 - Characteristics of studies in the meta-analysis that show an association between seroma
and use of drain or quilting sutures.
Table 3 - Main results and recommendations/conclusions of the studies included in the meta-analysis.
Author/Year |
Sample |
Results |
Recommendations /Conclusions |
Arantes HL et al.2 |
60 |
Drain (n = 29) and drain and quilting sutures (n = 31) were used. Seroma formation
rate were 3.45% in the first group and 3.2% in the second group.
|
Quilting sutures were considered effective for preventing seroma formation, even without
statistical significance between the groups.
|
Soncini JA et al.1 |
500 |
Drain (n = 192) and drain and quilting sutures (n = 308) were used. Seroma formation
rates were 15.6% in the first group and 23.7% in the second group.
|
Quilting sutures were efficient in preventing seroma. The use of aspiration drain
did not diminish the incidence of seroma formation.
|
Oliveira EA et al.4 |
58 |
Drain (n = 25) and drain and quilting sutures (n = 30) were used. |
Adhesion points inhibited the formation of seroma with statistical significance (p
<0.05).
|
Sforza M et al.8 |
326 |
Drain (n = 100) and drain and quilting sutures (n = 226) were used. The seroma formation
rates were 12% in the first group and 0% in the second group.
|
There was no difference between the use of quilting sutures or drains. |
Trufino AJ5 |
34 |
Drain (n = 17) and drain and quilting sutures (n = 17) were used. The seroma formation
rates were 17.64% in the first group and 0% in the second group.
|
The quilting sutures showed advantages reduction of the complications compared to
the control group.
|
Table 3 - Main results and recommendations/conclusions of the studies included in the meta-analysis.
Due to the lack of any important diversity and heterogeneity, the fixed effects method
was used in all analyses, which assumes that all studies showed the same effect. The
studies that assessed the rate of postoperative seroma with the use of quilting sutures
versus drains indicate lower rates of seroma in the group that used quilting sutures
only; thus, it is considered a protective factor (RR, 0.13; 95% CI, 0.02-0.66) (Figure 2A).
When comparing the groups that use only quilting sutures versus quilting sutures + drain, a protection against the formation of seroma was observed
in the group that used only quilting sutures (RR, 0.66; 95% CI, 0.45-0.97), as shown
in Figure 2B. When comparing the groups that used only drain versus quilting sutures + drain the group that used quilting sutures + drain displayed a
lower rate of formation of seroma (RR, 0.06; 95% CI, 0.01-0.29) (Figure 2C).
Figure 2 - Combined analysis of the relative risk of seroma formation according to the use of
drains or quilting sutures.
Figure 2 - Combined analysis of the relative risk of seroma formation according to the use of
drains or quilting sutures.
DISCUSSION
According to the results obtained for each article analyzed in this study, the use
of quilting sutures was significantly better in protecting against seroma when compared
to techniques using drain alone or drain associated with the quilting sutures.
Suction drains were believed to improve the approximation of bloody areas by better
surface apposition and reduce fluid accumulation, but their disadvantages have been
widely documented, such as ineffectiveness, discomfort, mobilization difficulty, rupture
or premature extrusion, bacterial colonization, tissue irritation, and increased seroma
formation9.
To mitigate these disadvantages, quilting sutures have been used since they reduce
flap mobility and thus the shear forces between the aponeurosis and the flap, facilitating
healing. Another characteristic that corroborates the decrease in seroma formation
is the reduction of dead space3.
Furthermore, the hospitalization stay of patients undergoing abdominoplasty, previously
determined by the volume of effluent collected in suction drains, was abbreviated
with the use of quilting sutures to a mean 24 hours, allowing an earlier return to
usual activities10.
Despite the technical peculiarities inherent to each surgeon, all authors followed
the principle of the quilting sutures technique described by Baroudi and Ferreira
(1996 and 1998, respectively)6, which basically consists of isolated quilting sutures that secure the cutaneous
flap on the aponeurosis of the rectus abdominis muscle spaced 4 cm apart between sutures
in rows and columns from the xiphoidal appendix to the pubic region bilaterally using
absorbable wires1.
The learning curve for quilting suture placement is short, so the execution time is
not significantly higher than that of other surgical techniques; thus, no increase
in the risk of complications is implied. As in the treatment of seroma, several punctures
are usually required, and use of this technique prevents postoperative disorders3.
Despite the comprehensive literature review, this meta-analysis has some limitations,
such as the lack of data on participants' BMI and the non-description of randomization
in all studies (which may have interfered with the study outcome since people at higher
risk of seroma development may have been treated with drains and different associated
techniques such as the use of abdominal liposuction).
Nevertheless, the work of Oliveira et al. in 20084 indicated that upper abdominal liposuction associated with limited flap dissection
did not increase the rate of complications. Another relevant point is the lack of
standardization regarding the criteria for drain removal; early withdrawal of the
drain could increase the incidence of seroma formation.
CONCLUSION
Although studies involved in the literature review did not use patient randomization,
which would provide greater scientific evidence, these results suggest that the use
of quilting sutures alone is superior to the use of drains or the use of drains with
quilting sutures. We also recommend that researchers perform randomized clinical trials
to aid in the decision-making process for surgical procedures based on a high level
of evidence.
COLLABORATIONS
KGM
|
Analysis and/or data interpretation, Conception and design study, Data Curation, Final
manuscript approval, Formal Analysis, Methodology, Writing - Original Draft Preparation,
Writing - Review & Editing
|
CFR
|
Analysis and/or data interpretation, Data Curation, Final manuscript approval, Formal
Analysis, Writing - Original Draft Preparation, Writing - Review & Editing
|
FGC
|
Final manuscript approval, Supervision, Writing - Original Draft Preparation, Writing
- Review & Editing
|
KGM
|
Analysis and/or data interpretation, Final manuscript approval, Formal Analysis, Methodology,
Supervision, Writing - Original Draft Preparation, Writing - Review & Editing
|
REFERENCES
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mas com pontos de adesão. Rev Bras Cir Plást. 2015;30(4):522-532.
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7. Kempen JH. Appropriate use and reporting of uncontrolled case series in the medical
literature. Am J Ophthalmol. 2011 Jan;151(1):7-10.e1.
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Use of quilting sutures during abdominoplasty to prevent seroma formation: are they
really effective?. Aesthet Surg J. 2015;35(5):574-80.
9. Bhave MA. Can drains be avoided in lipo-abdominoplasty?. Indian J Plast Surg. 2018
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1. Hospital Santa Casa de Misericórdia de Vitória, Vitória, ES, Brazil.
2. Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
Corresponding author: Katrienne Guidolini Martinelli Rua Deolindo Perim, 371, Praia de Itaparica, Vila Velha, ES, Brazil. Zip code: 29102-050.
E-mail: katriennegm@gmail.com
Article received: January 26, 2019.
Article accepted: July 8, 2019.
Conflicts of interest: none.