Introduction: The benefits of the interruption of the tabagism previously the surgery not yet well are defined. Objective: The objective of this study was to assess the influence of the interruption of exposure to nicotine on a cutaneous flap, by laser flowmetry and picrosirius. Method: 56 rats were used, divided in groups and administred nicotine 2mg/kg/day, 0,5mg/kg/day and just saline solution. Animals were subdivided according to exposure time to the drug, that is, in one and two weeks' interruption prior to surgery, and constant treatment up to ten days after surgical procedure. They were organized in seven groups. A cutaneous flap was performed on the animals' dorsum and on the tenth day of PO the laser flow measurement and the formation of collagen and its differentiation in mature and immature by picrosirius. Results: The flowmetry was bigger in the control and the groups of low doses. The interruption of the drug only showed increase of the flowmetry in the groups of low dose. The ratio of mature colageno for immature was inversely proportional to the dose and the time of exposition to the drug. Conclusion: The nicotine harms the evolution of a remnant cutaneous of the back of rats, being dependent of the dose. The interruption time modifies the flowmetry and the ratio of formation of colageno, when given in low dose.
Keywords: Nicotine. Laser-doppler flowmetry. Surgical flaps. Picrates.